Confirmation of the antibacterial mode of action of SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp.
نویسندگان
چکیده
The compound designated SB-219383 is a potent and selective inhibitor of bacterial tyrosyl tRNA synthetases. It exhibits an IC50 of < 1 nM against Staphylococcus aureus tyrosyl tRNA synthetase and weak in vitro activity against Staphylococci and Streptococci. Here we present data consistent with SB-219383 eliciting an amino acid starvation in both S. aureus and Streptococcus pneumoniae, supporting the conclusion that the antibacterial activity of SB-219383 is due to tyrosyl tRNA synthetase inhibition.
منابع مشابه
THE JOURNAL OF ANTIBIOTICS SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonosporasp. II. Structure Determination
SB-219383 (1), isolated from fermentation broth of a novel species ofMicromonospora sp. NCIMB40684, is the first member of a new class of compounds having inhibitory activity against tyrosyl tRNA synthetase (IC50, 2nM). SB-219383 also exhibits moderate in vitro activity against some Gram-positive bacteria. The preceding paper describes the fermentation, isolation, physico-chemical and biologica...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 55 4 شماره
صفحات -
تاریخ انتشار 2002